Herbalzym is an alternative medical organization dedicated to developing treatment protocols for a diversity of diseases using natural medicine. For over 10 years, Herbalzym formula had been used with great success on so many terminally ill patients. It had been proven over and over again to be effective in clinical trials.
The protein AMPK (AMP-activated protein kinase) is a key player in regulating cell growth and metabolism. It is emerging as an important modulator of energy metabolism in cancer cells and thereby regulating their growth. AMPK is a fuel sensing enzyme (cellular fuel-gauge) that is activated by hormones, cytokines, exercise, and stresses that diminish cellular energy state (e.g., glucose deprivation).
AMPK is activated during periods of stress conditions such as hypoxia (low oxygen supply to a tissue), ischemia (reduction in blood flow to a tissue) where the intracellular AMP level or the ratio of AMP to ATP is increased. It shifts the metabolism of cells from an anabolic to a catabolic state in order to maintain their survival. This means that the synthesis of cholesterol, fatty acids and triglycerides, cell cycle inhibition, …
Prostate cancer originates from a rare subpopulation of cells, namely prostate cancer stem cells. Cancer stem cells (CSCs), a small population of cells in the tumor (less than 1%), play a significant role in the development and recurrence of several cancers. These cells have a substantial characteristic of stem cells ability for self-renewal without loss of proliferation capacity with each cell division. Furthermore they are immortal, rather resistant to treatment and express typical markers of stem cells. The origin of these resident CSCs is not clear.
Conventional therapies for prostate cancer are believed to mainly target the majority of differentiated tumor cells but left these CSCs untouched. It causes relapses in the cancer by producing new chemo-resistant cancer cells. …
The normal development and maintenance of the prostate is dependent on androgen acting through the androgen receptor (AR). In the normal prostate, the rate of cell death is 1–2% per day, and replaced with new ones. This activity is part of normal prostate function and is regulated by AR. Thus, maintaining natural balance in the function of AR is a key to prostate health.
AR exists as a phosphoprotein and its function is tightly regulated. When testosterone or DHT is present, it binds to complex, which causes to dissociate from heat shock protein (Hsp), binds to DNA at specific location. This forms ligand-dependent transcription factor, which can increase or decrease the regulation of gene.
Both androgen dependent and independent prostate cancers can be successfully treated with natural medicines. Prostate cancer cells depend primarily …
We now know that PSA (prostate specific antigen) is a serine protease produced by both prostate epithelial cells and prostate cancer. The serine proteases are a family of enzymes that cut certain peptide bonds in other proteins. Thus, PSA has enzymatic ability to degrade extracellular matrix (structural support) proteins such as fibronectin and laminin. This action of PSA may promote tumor growth, invasion and metastasis of prostate cancer.
Another potential tumor-promoting action of PSA involves freeing insulin-like growth factor 1 (IGF-1) from its binding protein (BP-3), providing increased local levels of IGF-1 and leading to tumor growth. IGF-1, generally secreted by the liver as a result of stimulation by growth hormone (GH), is important in both …
As discussed in part three on prostate cancer, telomerase and telomeres are attractive targets for anticancer therapy. Tumors have relatively shorter telomeres compared to normal cell types. But, in cancer cells an enzyme called telomerase keeps rebuilding the telomeres, and the cancer cells go on dividing without control and are able to invade other tissues. Telomerase is active in most human cancers and over 90% of prostate cancers express telomerase activity. Telomerase inhibitors induce telomere shortening in cancer cells and cessation of unrestrained proliferation. Silibinin, an active constituent of milk thistle, can also inhibit the telomerase activity.
In addition, Silibinin can also kill prostate cancer cells directly and restrict tumors’ ability to grow the new blood vessels through multiple mechanisms. It …
Zinc is necessary for the production of testosterone and inhibiting the enzymatic activity of prostate specific antigen (PSA), a marker for the diagnosis and monitoring of prostate cancer. PSA is a protein produced by cells of the prostate gland. PSA is specific to the prostate and is not cancer-specific. Therefore elevated levels of PSA is seen in an array of condition such as prostatitis (inflammation of the prostate) and benign hypertrophy of the prostate (enlargement of the prostate) besides prostate cancer.
PSA could play a role in prostate cancer cell growth, migration and invasion. PSA is a serine protease with a molecular weight of approximately 33 kDa. The serine proteases are a family of enzymes that cut certain peptide bonds in other …
The roles of zinc in the body are numerous. Among other things, it serves to boost immune functions and plays a significant role in healing processes and the development of healthy bones. Lesser known, but equally essential roles include helping with the formation of hundreds of enzymes, and assisting with gene transcription and RNA and DNA metabolism. It’s found in the tissues of the brain, kidneys, muscles, liver and bones; however the highest concentration is found in the eye and the male prostate gland. Total zinc levels in the prostate are 10 times higher than in other soft tissues. It is known to be crucial to normal prostate function.
Zinc is essential to protecting against oxidative stress and …
Everyone’s mouth is full of oral bacteria— most of them harmless. Beneficial Helpful Bacteria or Friendly Bacteria or Probiotic Bacteria or Probiotics or Oral Probiotics are live microorganisms thought to be beneficial, helpful, and friendly to the host organism. The vast majority of bacteria are actually helpful and even necessary for good health. From the mouth to the anus, these tiny life forms aid in breaking down and digesting food, converting nutrients and dietary fiber for absorption, synthesizing vitamins, and degrading toxins. They also aid the immune system to develop vigorous responses.
In a healthy mouth there is a natural balance of different bacterial species. This natural balance keeps the harmful bacteria from becoming too strong or out of balance so as to dominate. They join together to form communities …
Are Harmful Bacteria Winning the War in Your Mouth?
Your mouth is a jungle! Like everywhere else in your body, your mouth is loaded with billions of bacteria constantly on the move. While some bacteria are harmless, others can attack the teeth and gums. Harmful bacteria are contained in a colorless sticky film called plaque, the cause of gum disease. If not removed, plaque builds up on the teeth and ultimately irritates the gums and causes bleeding. Left unchecked, bone and connective tissue are destroyed, and teeth often become loose and may have to be removed. Gum disease is not just a matter of oral discomfort, bad breath and loose teeth, but in fact it can also affect other parts of your body including some internal organs such as …
