The Magical Gut-Ecology Modulator “Flaxzym” that can restore digestive health, gut health, optimal immunity and body’s balance naturally.
If I told you there was just one and only, so good and tasty vegan paste that can help prevent and cure indigestion, bloating, gas, chronic constipation, diarrhea, irritable bowel, inflammatory bowel (UC, Chron’s), acid reflux, leaky gut, hemorrhoids, colon polyps, certain cancers like colon, breast, ovarian and prostate, chronic allergies, arthritis, autoimmune diseases, diabetes, heart disease, liver disease, high cholesterol, acne, eczema, atopic dermatitis, psoriasis, chronic fatigue, menopause syndrome, migraines, depression, anxiety, attention deficit disorder, and occasionally even autism and that it could help you lose weight quickly and easily without cravings, suffering, or deprivation, you might wonder if I had gone a little crazy. But it’s true. And the story goes like this.
Digestive health: all disease begins in the gut
Our gut is at the center of our health and is a key factor in our nutrition and in improving performance, immunity, energy, body composition, mood and many other important elements of our wellness. The gut is controlled by the enteric nervous system (ENS), a complex system of about 100 million nerves that oversees every aspect of digestion. And all those neurons lining our digestive system allow it to keep in close contact with the brain via the vagus nerves. Recent research is demonstrating that the gut is almost like “second brain” in its link and connection to so many other areas of our body’s mental and physical function.
Gut damage however is common and caused by a number of things:
1. Food allergies and gluten intolerance
2. Antibiotics and other medications
3. Diets high in refined carbohydrates, sugar and processed foods,
4. Diets low in fermentable fibers
5. Dietary toxins and heavy metals
6. Chronic infections
7. Low-grade chronic inflammation in the body
8. Chronic stress
9. Excessive alcohol consumption
10. Changes in body composition with ageing
Gut dysfunction can be linked to virtually every disease and can cause conditions like indigestion, constipation, diarrhea, leaky gut, hemorrhoids, weakned immunity, chronic infection, chronic fatigue, depression, anxiety, food sensitivities, reflux, chronic pain, autoimmune diseases, allergies, arthritis, obesity, diabetes, heart disease, liver disease, cancer, acne, eczema, atopic dermatitis, poor skin and more. At least 70 million people in the U.S. suffer from some sort of digestive illness (not including heartburn), and digestive problems account for nearly 10% of all healthcare spending.
What we eat can make or break our gut health
Our gut is one of the quickest parts in our body to repair itself. In a healthy gut lining, the epithelial cells that make up the mucosa are tightly packed together like a brick wall, and have contact points called tight junctions. This surface is semi-permeable, thereby allowing properly digested nutrients and water to enter into the body while preventing the entry of toxins and antigens. Repeated exposure to the toxins and antigens usually causes food allergies, food intolerances and/or inflammatory bowel diseases. This is commonly shown up with intestinal dysbiosis, candida overgrowth, leaky gut, abdominal pain and compromised immune function. A leaky gut often goes along with conditions such as: allergies, asthma, type 1 diabetes, mental illnesses (including depression and schizophrenia), autism, skin inflammation such as acne, rosacea, and eczema.
The importance of our gut microbiome cannot be overstated. The gut microbiome, which hosts up to 1000 bacterial species that encode about 5 million genes, is also known as “our forgotten organ”. Our gut bacteria can breakdown food the body can’t digest, produce important nutrients, regulate the production of antibodies by the immune system, send messages to our brain and helps regulate metabolism, and produce hundreds of neurochemicals that the brain uses to regulate basic physiological processes as well as mental processes such as learning, memory and mood. Our gut is especially vulnerable to the presence of chronic (and even acute) stress, demonstrating stress-induced changes in gastric secretion, gut motility, mucosal permeability and barrier function, visceral sensitivity and mucosal blood flow.
Good food is great medicine
A healthy, balanced gut microbiome promotes a strong immune system and lower levels of chronic inflammation. An unhealthy gut microbiome has been linked to nearly every disease. The relationship between food and the gut microbiome is a two-way street: The food we eat affects the composition of gut microbiome, and the composition of gut microbiome affects how we digest and absorb our food.
Not only can that an inadequate diet will also lead to the damage of gut function. Diets that lack tissue building protein, fats and fat soluble nutrients, minerals and vitamins can contribute to the breakdown of gut function. A distressed or damaged gut can’t act in our defense. Instead, it allows dangerous compounds to enter into the body. While it is true, useful and sometimes very necessary that we receive emergency treatment, medication or surgery, we must understand that our body is a self-healing mechanism. Our body’s innate Intelligence is ready, willing and able to repair our body – IF it receives the vital substances to optimally function and blissfully elevate our health. All of the vital substances in good food that our body needs to function properly and repair itself are great medicine that can prevent, reverse, and even cure disease.
What we do to maintain and restore digestive health: Heal the gut and heal yourself
So we come to the question, what must we do? Here are some of the best ways to maintain and restore a healthy gut naturally.
1. Remove all food toxins from your diet
2. Eat plenty of fermentable fiber from diverse natural sources.
3. Eat different types of fermented foods that contain a lot of friendly probiotic bacteria.
4. Eat plenty of peptides, enzymes and bioavailable lignans generated during the fermentation process
5. Eat anti-inflammatory bioactive nutrients to help the gut repair itself
6. Take steps to manage your stress
Can you figure out which food will be the best one that works for your gut health?
You are now being offered a magical solution to improve gut microbiome and nutrient absorption, help heal GI tract lining, strengthen the digestive system, reduce inflammation, boost immunity, control appetite, regulate lipid and protein metabolism, balance hormones, improve neurological function, and recover body’s balance and overall health at the same time. This wonderful solution is the fermented golden flaxseed based paste “FLAXZYM”.
“FLAXZYM” was developed in Canada. It is designed to support the GI system with all the tools necessary to enhance digestion and bio-active nutrient absorption and support the cultivation of a healthy microbiome. “FLAXZYM” is so good and tasty gut-ecology paste. It is made from Canadian golden flaxseeds, fermented organic fruits, organic seeds, organic plant roots and enzymes, anti-inflammatory and immune modulating nutrients. And “FLAXZYM” is uniquely fermented by the enzymatic and microbial method. It contains everything we need to restore our digestive system and whole healthy body, including soluble and insoluble fermentable fibers, prebiotics, probiotics, synbiotics, peptides, enzymes and bioavailable mammalian lignans generated during the fermentation process, digestive enzymes, butyrate, short chain fatty acids, omega-3 fatty acids, bioactive essential fatty acids, vitamin B complex, anti-inflammatory and immune modulating bioactive nutrients.
Lignan is a chemical found in the cell walls of plants. The main lignan from flaxseed hull is SDG (secoisolariciresinol diglucoside). When SDG is ingested it is metabolised in the gut by bacterial breakdown into the mammalian lignans, enterodiol and enterolactone. Cleavage of sugar chains must occur for SDG flax hull lignan, by the enzymatic and microbial fermentation, before the mammalian lignans are formed. This may offer efficacy advantages to enzymatically, microbially fermented “FLAXZYM”.
Mammalian lignans are antioxidants that may also support the immune system and are excellent for balancing hormone levels in the body. They also have anti-estrogenic effects and can prevent naturally occurring (and sometimes radical) hormones from binding to estrogen receptors and exerting their negative effects. Lignans provide a weaker, cleaner estrogen to balance any deficit or surplus.
Mammalian lignans from “FLAXZYM” is readily and completely absorbed in the digestive tract. Thus, the best bioavailability and most rapid uptake occurs for enterolactone and enterodiol formed from “FLAXZYM”.
Appetite control: “FLAXZYM” can control hunger hormones.
To lose weight, we generally need to reduce our daily calorie intake. Unfortunately, weight loss diets often lead to increased appetite and severe hunger. Even though we are not physically hungry, our body gave us the signal to eat. That?s the work of three hormones in our body that control hunger ? insulin, ghrelin and leptin. This can make it extremely difficult to lose weight and keep it off. The good new is that “FLAXZYM” can help reduce hunger, suppress appetite, eat less, and ultimately lose more weight.
“FLAXZYM” stretches the stomach, slows its emptying rate and influences the release of fullness hormones. “FLAXZYM” contains healthy probiotics that are similar to those that live in our digestive tract. Thease healthy probiotics start producing new proteins that have some inhibiting effect on appetite. Our randomized trial demonstrating that increased “FLAXZYM” consumption is an effective weight loss strategy. Furthermore, there is evidence that “FLAXZYM” could help The Skinny people Gain Weight.
“FLAXZYM” protects against the health problems including indigestion, bloating, gas, chronic constipation, diarrhea, irritable bowel, inflammatory bowel (UC, Chron’s), acid reflux, leaky gut, hemorrhoids, bowel obstruction, colon polyps, and certain cancers like colon, breast and prostate. “FLAXZYM” could also help prevent and cure many other health issues including chronic allergies, arthritis, obesity, increased appetite (emotional eating), autoimmune diseases, diabetes, heart disease, liver disease, high cholesterol, ageing skin, acne, eczema, atopic dermatitis, psoriasis, chronic fatigue, menopause syndrome, migraines, depression, anxiety, attention deficit disorder, and occasionally even autism.
Simply eat “FLAXZYM” and enjoy all the comforts of restored digestion and gut function, optimized immunity and integrated whole and all systems working together.
Golden Flaxseed – Scientific Research
Currently, flaxseed has been the focus of increased interest in the field of diet and disease research due to the potential health benefits associated with some of its biologically active components such as fermentable dietary fiber, omega-3 fatty acids, lignans and minerals.
Among the compounds that present biological activity, lignans are of special interest. Lignans, very complex classes of bio-active polyphenolic phytochemicals, are widely distributed in the plant kingdom. Flaxseed is particularly the richest source of lignans (9–30 mg per g), with lignan production at 75–800 times that of other oil seeds, cereals, legumes, and fruit and vegetables.
There are two general types of lignans: i) those found in plant seeds like secoisolariciresinol diglucoside (SDG), isolariciresinol, matairesinol, lariciresinol and ii) those found in animals and humans known as mammalian lignans. The principal dietary lignan present in flaxseed is SDG which occurs as a component of a linear ester-linked complex. Plant lignans can be converted by intestinal bacteria into the bioavailable lignans, so-called enterolignans, enterodiol and enterolactone.
⦁ Flaxseeds are the richest dietary source of fermentable dietary fiber, omega-3 fatty acids and lignan precursors.
⦁ When consumed, lignan precursors are converted to the bioavailable enterolignans, enterodiol and enterolactone, by bacteria that normally colonize the human intestine.
Lignan-rich foods like flaxseed are a healthful dietary pattern in the prevention of hormone-associated cancers, osteoporosis, cardiovascular disease, diabetes, and menopause symptoms.
Flaxseed is also the richest source of soluble, insoluble and fermentable fiber. For years, researchers had us making distinctions between soluble fiber, the kind that forms a gel with water, slows our digestion and keeps our blood sugar even, and insoluble fiber, which bulks up our stool and prevents constipation. Now “fermentable” is becoming the new buzz word(although scientists have known about it for a long while).
Healthy bacteria in our gut feed on fermentable fiber and turn it into butyrate and other short chain fatty acids. Short-chain fatty acids produced when the gut bacteria ferment fiber in the gut are the main source of energy for the cells in the lining of our gut.
In turn, those fatty acids control appetite and blood sugar, regulate inflammation and improve our immune system. Butyrate also helps quiet genes that drive cancer and heal the intestinal lining, often damaged by chemotherapy.
One investigation discovered that adding more fiber to the diet can trigger a shift from a microbial profile linked to obesity to one correlated with a leaner physique. Another recent study shows that when microbes are starved of fiber, they can start to feed on the protective mucus lining of the gut, possibly triggering inflammation and disease.
References:
The bowel and beyond: the enteric nervous system in neurological disorders. Rao M, Gershon MD. Nat Rev Gastroenterol Hepatol. 2016 Sep;13(9):517-28.
Gut-brain axis: how the microbiome influences anxiety and depression. Foster JA, McVey Neufeld KA. Trends Neurosci. 2013 May;36(5):305-12
The gut microbiome and diet in psychiatry: focus on depression. Dash S, Clarke G, Berk M, Jacka FN. Curr Opin Psychiatry. 2015 Jan;28(1):1-6.
The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System. Obata Y, Pachnis V. Gastroenterology. 2016 Nov;151(5):836-844.
Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system. Kabouridis PS, Pachnis V. J Clin Invest. 2015 Mar 2;125(3):956-64.
Interactions between the microbiota and the immune system. Hooper LV, L ittman DR, Macpherson AJ. Science 2012;336:1268-73.
Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome. Borton MA, Sabag-Daigle A, Wu J, Solden LM, O’Banion BS, Daly RA, Wolfe RA, Gonzalez JF, Wysocki VH, Ahmer BMM, Wrighton KC. Microbiome. 2017 Apr 27;5(1):47
Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Goto Y, Kiyono H. Immunol Rev. 2012 Jan;245(1):147-63.
Treatment Algorithm for Chronic Idiopathic Constipation and Constipation-Predominant Irritable Bowel Syndrome Derived from a Canadian National Survey and Needs Assessment on Choices of Therapeutic Agents. Tse Y, Armstrong D, Andrews CN, Bitton A, Bressler B, Marshall J, Liu LW. Can J Gastroenterol Hepatol. 2017;2017:8612189
Current and emerging treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation: focus on prosecretory agents. Thomas RH, Luthin DR. Pharmacotherapy. 2015 Jun;35(6):613-30.
Functional Disorders: Slow-Transit Constipation. Tillou J, Poylin V. Clin Colon Rectal Surg. 2017 Feb;30(1):76-86.
The impact of ageing on the intestinal epithelial barrier and immune system. Man AL, Gicheva N, Nicoletti C. Cell Immunol. 2014 May-Jun;289(1-2):112-8.
Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing. Lawrence K, Hyde J. PLoS One. 2017 Jun 14;12(6):e0179017.
Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Diop L, Guillou S, Durand H. Nutr Res. 2008 Jan;28(1):1-5.
Towards an Integrative Understanding of Diet-Host-Gut Microbiome Interactions. Read MN, Holmes AJ. Front Immunol. 2017 May 8;8:538.
Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study. Stasi C, Bellini M, Gambaccini D, Duranti E, de Bortoli N, Fani B, Albano E, Russo S, Sudano I, Laffi G, Taddei S, Marchi S, Bruno RM. J Neurogastroenterol Motil. 2017 Apr 26.
Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome. Jin DC, Cao HL, Xu MQ, Wang SN, Wang YM, Yan F, Wang BM. World J Gastroenterol. 2016 Sep 28;22(36):8137-48
Gastrointestinal disorders associated with migraine: A comprehensive review. Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A. World J Gastroenterol. 2016 Sep 28;22(36):8149-60.
Functional relevance of intestinal epithelial cells in inflammatory bowel disease. Okamoto R, Watanabe M. Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(6):522-527.
Alcohol, Intestinal Bacterial Growth, Intestinal Permeability to Endotoxin, and Medical Consequences: Summary of a Symposium Vishnudutt Purohit, J. Christian Bode, Christiane Bode, David A. Brenner, Mashkoor A. Choudhry, Frank Hamilton, Y. James Kang, Ali Keshavarzian, Radhakrishna Rao, R. Balfour Sartor, Christine Swanson, Jerrold R. Turner. Alcohol. 2008 Aug; 42(5): 349–361.
Diet and microbiota in inflammatory bowel disease: The gut in disharmony. Rapozo DC, Bernardazzi C, de Souza HS. World J Gastroenterol. 2017 Mar 28;23(12):2124-2140.
Is intestinal inflammation linking dysbiosis to gut barrier dysfunction during liver disease? Brandl K, Schnabl B. Expert Rev Gastroenterol Hepatol. 2015;9(8):1069-76.
Diet, microorganisms and their metabolites, and colon cancer. O’Keefe SJ. Nat Rev Gastroenterol Hepatol. 2016 Dec;13(12):691-706.
Gastrointestinal microbiome and breast cancer: correlations, mechanisms and potential clinical implications. Yang J, Tan Q, Fu Q, Zhou Y, Hu Y, Tang S, Zhou Y, Zhang J, Qiu J, Lv Q. Breast Cancer. 2017 Mar;24(2):220-228
Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome. Ussar S, Fujisaka S, Kahn CR. Mol Metab. 2016 Jul 18;5(9):795-803.
From the gastrointestinal tract (GIT) to the kidneys: live bacterial cultures (probiotics) mediating reductions of uremic toxin levels via free radical signaling. Vitetta L, Linnane AW, Gobe GC. Toxins (Basel). 2013 Nov 7;5(11):2042-57.
Can probiotics modulate human disease by impacting intestinal barrier function? Bron PA, Kleerebezem M, Brummer RJ, Cani PD, Mercenier A, MacDonald TT, Garcia-Ródenas CL, Wells JM. Br J Nutr. 2017 Jan;117(1):93-107.
Ecological and evolutionary forces shaping microbial diversity in the human intestine. Ley RE, Peterson DA, Gordon JI. Cell. 2006 Feb 24;124(4):837-48.
Gut Microbiota Modulation and Its Relationship with Obesity Using Prebiotic Fibers and Probiotics: A Review Dinesh K. Dahiya, Renuka, Monica Puniya, Umesh K. Shandilya, Tejpal Dhewa, Nikhil Kumar, Sanjeev Kumar, Anil K. Puniya, Pratyoosh Shukla. Front Microbiol. 2017; 8: 563.
Probiotics, prebiotics and synbiotics- a review. Pandey KR, Naik SR, Vakil BV. J Food Sci Technol. 2015 Dec;52(12):7577-87.
New approaches for bacteriotherapy: prebiotics, new-generation probiotics, and synbiotics. Patel R, DuPont HL. Clin Infect Dis. 2015 May 15;60 Suppl 2:S108-21.
Therapeutic Application of Synbiotics, a Fusion of Probiotics and Prebiotics, and Biogenics as a New Concept for Oral Candida Infections: A Mini Review. Ohshima T, Kojima Y, Seneviratne CJ, Maeda N. Front Microbiol. 2016 Jan 25;7:10.
Microbiome in atopic dermatitis. Wollina U. Clin Cosmet Investig Dermatol. 2017 Feb 22;10:51-56.
Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem. Eeckhaut E, Struijs K, Possemiers S, Vincken JP, Keukeleire DD, Verstraete W. J Agric Food Chem. 2008 Jun 25;56(12):4806-12
Ruminal Prevotella spp. may play an important role in the conversion of plant lignans into human health beneficial antioxidants. Schogor AL, Huws SA, Santos GT, Scollan ND, Hauck BD, Winters AL, Kim EJ, Petit HV. PLoS One. 2014 Apr 7;9(4):e87949.
Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Adolphe JL, Whiting SJ, Juurlink BH, Thorpe LU, Alcorn J. Br J Nutr. 2010 Apr;103(7):929-38.
Flaxseed and cardiovascular health. Prasad K. J Cardiovasc Pharmacol. 2009 Nov;54(5):369-77.
Dietary lignans: physiology and potential for cardiovascular disease risk reduction. Peterson J, Dwyer J, Adlercreutz H, Scalbert A, Jacques P, McCullough ML. Nutr Rev. 2010 Oct;68(10):571-603.
Flaxseed and Diabetes. Prasad K, Dhar A. Curr Pharm Des. 2016;22(2):141-4. Review.
Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study. Turowski JB, Pietrofesa RA, Lawson JA, Christofidou-Solomidou M, Hadjiliadis D. BMC Complement Altern Med. 2015 May 13;15:148
Flaxseed consumption may reduce blood pressure: a systematic review and meta-analysis of controlled trials. Khalesi S, Irwin C, Schubert M. J Nutr. 2015 Apr;145(4):758-65
The potential health effects of dietary phytoestrogens. Rietjens IMCM, Louisse J, Beekmann K. Br J Pharmacol. 2017 Jun;174(11):1263-1280
Enterolactone Suppresses Proliferation, Migration and Metastasis of MDA-MB-231 Breast Cancer Cells Through Inhibition of uPA Induced Plasmin Activation and MMPs-Mediated ECM Remodeling Mali AV, Joshi AA, Hegde MV, Kadam ShS. Asian Pac J Cancer Prev. 2017 Apr 1;18(4):905-915.
Enterolactone Reduces Telomerase Activity and The Level of Its Catalytic Subunit in Breast Cancer Cells. Ilbeigi D, Nourbakhsh M, Khaghani S, Einollahi N, Kheiripour N, Gholinejad Z, Alaee M, Saberian M. Cell J. 2017 Spring;19(Suppl 1):37-43.
Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. Zhu Y, Kawaguchi K, Kiyama R. PLoS One. 2017 Feb 2;12(2):e0171390
Dietary fat and fiber interactively modulate apoptosis and mitochondrial bioenergetic profiles in mouse colon in a site-specific manner. Fan YY, Vaz FM, Chapkin RS. Eur J Cancer Prev. 2017 Jul;26(4):301-308
Chemoprotective epigenetic mechanisms in a colorectal cancer model: Modulation by n-3 PUFA in combination with fermentable fiber. Triff K, Kim E, Chapkin RS. Curr Pharmacol Rep. 2015 Feb;1(1):11-20.
Prebiotics: why definitions matter. Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey G Jr, Goh YJ, Hamaker B, Martens EC, Mills DA, Rastal RA, Vaughan E, Sanders ME. Curr Opin Biotechnol. 2016 Feb;37:1-7.
Effects of Prebiotics and Synbiotics on Functional Constipation. Yu T, Zheng YP, Tan JC, Xiong WJ, Wang Y, Lin L. Am J Med Sci. 2017 Mar;353(3):282-292. doi: 10.1016/j.amjms.2016.09.014
Dietary fibres modulate the composition and activity of butyrate-producing bacteria in the large intestine of suckling piglets. Mu C, Zhang L, He X, Smidt H, Zhu W. Antonie Van Leeuwenhoek. 2017 May;110(5):687-696
The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. Schwarz A, Bruhs A, Schwarz T. J Invest Dermatol. 2017 Apr;137(4):855-864.
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. Cell. 2016 Jun 2;165(6):1332-1345.
Impact of Glycosidic Bond Configuration on Short Chain Fatty Acid Production from Model Fermentable Carbohydrates by the Human Gut Microbiota. Harris HC, Edwards CA, Morrison DJ. Nutrients. 2017 Jan 1;9(1). pii: E26.
Towards microbial fermentation metabolites as markers for health benefits of prebiotics. Verbeke KA, Boobis AR, Chiodini A, Edwards CA, Franck A, Kleerebezem M, Nauta A, Raes J, van Tol EA, Tuohy KM. Nutr Res Rev. 2015 Jun;28(1):42-66
In vitro bacterial fermentation of tropical fruit fibres. Vong MH, Stewart ML. Benef Microbes. 2013 Sep;4(3):291-5.
Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet. Ojo B, El-Rassi GD, Payton ME, Perkins-Veazie P, Clarke S, Smith BJ, Lucas EA. J Nutr. 2016 Aug;146(8):1483-91.
Short-chain fatty acids in control of body weight and insulin sensitivity. Canfora EE, Jocken JW, Blaak EE. Nat Rev Endocrinol. 2015 Oct;11(10):577-91
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Canfora EE, van der Beek CM, Jocken JWE, Goossens GH, Holst JJ, Olde Damink SWM, Lenaerts K, Dejong CHC, Blaak EE. Sci Rep. 2017 May 24;7(1):2360.
Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms? Chambers ES, Morrison DJ, Frost G. Proc Nutr Soc. 2015 Aug;74(3):328-36
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility. Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, Young VB, Henrissat B, Wilmes P, Stappenbeck TS, Núñez G, Martens EC. Cell. 2016 Nov 17;167(5):1339-1353.e21