FoxM1 (forkhead box protein M1) protein is a member of the Fox (forkhead box) family of transcription factors with known roles in regulating cell cycle progression. FOXM1 is a master regulator of cancer cell growth and is overexpressed in a majority of cancers, while its expression usually low in normal cells. Elevated FoxM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system. In addition, FoxM1 may drive tumor invasion, angiogenesis, and metastasis. For these reasons, FoxM1 is an attractive target for anticancer drugs such as doxorubicin, epirubicin and cisplatin.
FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells. Wnt3a increases the level and nuclear translocation of FoxM1, which binds …
