EGCG (epigallocatechin gallate) is the most abundant and perhaps most important catechin found in green tea (camellia sinensis). Catechins are polyphenolic antioxidant plant metabolites and belong in the flavonoid family. EGCG functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy.
There is a huge literature showing that EGCG kills cancer cells of all kinds. EGCG reactivates epigenetically silenced genes in cancer cells and induces apoptosis and promotes cell growth arrest, by altering the expression of cell cycle regulatory proteins, activating killer caspases, and suppressing nuclear factor kappa-B (NF-kB) activation.
The majority of human cancers demonstrate the inactivation of the p53 pathway. p53 …
