We are going to talk about statin cholesterol lowering drugs and their incredible ability to kill outright or sensitize cancer cells to chemo drugs or natural medicines. Anti-cholesterol drugs like statins are useful in the treatment of cancer simply because they block the activity of the enzyme HMG CoA reductase, the enzyme that makes mevalonate in the cell. Mevalonate, a precursor for cholesterol, inhibits prgrammed cell death in cancer cell/leukemia cells. The principal mechanism of any anticancer effects from statin use arises from prolonged lowering of circulating cholesterol and induction of cell cycle arrest. Evidence suggests that prostate cancer, ovarian cancer, lung cancer, colon cancer and leukemia might be particularly sensitive to this intervention. Many statins are available on prescription and are inexpensive, off-patent generic drugs those are immediately available for use as anti-cancer agents. However, the efficacy of these drugs can be negated by a high intake of dietary cholesterol. Therefore, it is critical that people adopt a low cholesterol diet and stick to it.
The impact of HMG-CoA reductase therapy on serum PSA.
In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent.
There is increasing evidence that the immune hormone IL-18 plays a major role in the integration of the innate, or non-specific, and genetic immune systems. Statin drugs may be attributed to their ability to release IL-18 from different white blood cells.
Hypothesis: the antitumor activities of statins may be mediated by IL-18.
Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells.
Tocotrienols are members of the vitamin E family. The combination of tocotrienols and statin drugs showed a synergistic inhibition of cancer cell growth
Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1.
Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo.
Statin drugs are the top selling class of prescription medications. But, we have the more powerful Natural Alternative to Statin Drugs. Policosanol is technically not a sugar at all. It’s a group of eight to nine “long chain alcohols” (solid, waxy compounds). It actually contains no sugar and has no extra calories so it doesn’t have an adverse effect on blood sugar levels. Research is accumulating to show that policosanol is more effective than the most popular patent medicines for lowering total cholesterol and triglyceride levels. As added bonuses, policosanol helps to prevent strokes by inhibiting platelet aggregation and abnormal blood clotting and may lower blood pressure. And unlike the popular patent medications, policosanol has virtually no side effects, and does not seriously interfere with our body’s ability to produce co-enzyme Q10 as the statins do.
Phytosterols, also known as plant sterols, are a naturally occurring class of compounds found in the cells and membranes of plants. These plant lipid-like compounds are present at low levels in grains, fruits and vegetables. There are approximately 250 different sterols and related compounds in plant and marine materials with the most common ones beta-sitosterol, stigmasterol, and campesterol.
Dietary phytosterols appear to play an important role in the regulation of serum cholesterol and to exhibit anticancer properties. Phytosterol and stanol (or phytosterols) consumption reduces intestinal cholesterol absorption, leading to decreased blood LDL-cholesterol levels Considerable emerging evidence supports the inhibitory actions of phytosterols on lung, stomach, as well as ovarian and breast cancer. Phytosterols seem to act through multiple mechanisms of action, including inhibition of carcinogen production, cancer-cell growth, angiogenesis, invasion and metastasis, and through the promotion of apoptosis of cancerous cells. Phytosterol consumption may also increase the activity of antioxidant enzymes and thereby reduce oxidative stress. In addition to altering cell-membrane structure and function, phytosterols probably promote apoptosis by lowering blood cholesterol levels.
Anticancer effects of phytosterols.
Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer.
Cholesterol-lowering effect of plant sterols.
Disease is a complex interaction of many different biochemical pathways and one perspective on the disease, from whatever scientific viewpoint you choose, is never going to be enough. Diseases involve living animals and everything, including stress, plays a role in their progression. It’s difficult to duplicate stress in a culture dish or experimental animal. Nevertheless, scientific research conducted in culture dishes has provided us with a wealth of information on how to block many disease processes, if only we paid attention. Naturally, we rarely do. Unlike many other supplements whose claims are supported solely by traditional wisdom or laboratory tests, SinnolZym has demonstrated its abilities in human trials — trials that compared its performance head to head with top-selling statin drugs. SinnolZym even outperformed the statins massively.
